在全球产业数智化转型与我国“制造强国”战略深度推进的双重背景下，制造业与数字经济的深度融合已成为区域产业突破发展瓶颈、实现高质量发展的核心路径。贵州作为全国首个大数据综合试验区，依托数字基础设施优势与制造业转型需求，在数实融合领域开展了诸多实践。本文系统梳理数智化背景下贵州制造业与数字经济融合的现状，发现贵州制造业与数字经济融合仍面临数字技术应用断层、融合生态不健全、专业人才短缺等问题，并提出相应优化建议，以期为贵州制造业突破数实融合梗阻、打造西部制造业数智化转型标杆提供理论参考与实践指导。

Under the background of the global industrial digital and intelligent transformation and the in-depth advancement of China’s “Manufacturing Powerhouse” strategy, the integration of the manufacturing industry and the digital economy has become a core path for regional industries to break through bottlenecks and achieve high quality development. As China’s first national big data comprehensive pilot zone, Guizhou, leveraging its advantages in digital infrastructure and the transformation needs of its manufacturing sector, has carried out numerous practices to integrate the real and digital economy. This paper systematically sorts out the current status of the integration of Guizhou’s manufacturing industry and the digital economy, and finds that it still faces problems such as gaps in the application of digital technologies, an underdeveloped integration ecosystem, a shortage of professional talents. Corresponding suggestions are put forward to provide reference and guidance for Guizhou’s manufacturing industry, so as to break through the obstacles and build a benchmark for manufacturing in western China.