Faced with the complex and ever-changing international market environment, Guizhou agricultural industrialization enterprises face many challenges in international operations. Through SWOT analysis, the advantages, disadvantages, opportunities, and threats of Guizhou agricultural industrialization enterprises based on core competitiveness in international operations are clarified. Based on this, strategic implementation paths such as restructuring enterprise organizational structure, transforming enterprise business models, and cultivating international talents have been proposed, aiming to provide theoretical support and practical guidance for the international operation of Guizhou agricultural industrialization enterprises.