Taking the construction of the Yangtze River Estuary Industrial Innovation and green development Collaborative Zone as an opportunity and background, this paper starts with the bottleneck problem of Nantong narrowing the intellectual property development gap with Shanghai and Suzhou, enhancing exchanges and cooperation, and promoting intellectual property to play a role in supporting regional collaborative innovation, and focuses on analyzing the patent data of Nantong City in recent years, especially the effective invention patent data, from the perspective of patents. From the perspective of innovation main body, industrial structure, patent transformation and application, it focuses on comparison, and seeks solutions to current problems.