Based on the WSR (Wuli - Shili - Renli) methodology, this paper analyzes the constituent elements, operational mechanisms, existing problems and optimization strategies of the discipline coordination and scientific research output system in local universities. It proposes the following research optimization strategies for such a system. The strategies include: (1) Strengthen top-level design and optimize the layout of disciplines; (2) Srengthen scientific research connection and serve regional needs; (3) Enhance the efficiency of resource allocation; (4) Build an interdisciplinary cooperation ecosystem; (5) Improv the evaluation system to stimulate research vitality; (6) Create a collaborative innovation culture.