Under the guidance of China's national strategies of “Digital China” and “Manufacturing Power,” the digital economy has become a core engine driving high-quality regional economic development. As the country’s first comprehensive big data pilot zone, Guizhou represents a historic convergence between its advantages in digital economic development and the needs of its manufacturing industry’s transformation and upgrading [1]. This paper takes Guizhou Tyre Co., Ltd.—an exemplary case of digital transformation in traditional manufacturing— as an example to conduct an in-depth analysis of its innovative practices in achieving deep integration through the digital economy. The case demonstrates that an innovation path centered on intelligent transformation, platform based collaboration, and data value realization can effectively help traditional manufacturing reduce costs, improve efficiency, and enhance core competitiveness. It provides a valuable practical model for promoting high-quality development in manufacturing industries in Guizhou and other similar regions in Western China [2].