Cultivating highly skilled talents for the low-altitude economy is a necessary move for higher vocational colleges to align with the national emerging industry strategy and achieve high-quality development of their own. Currently, higher vocational colleges face several challenges in talent cultivation: insufficient adaptability of program layout to the low-altitude industrial chain, weakened technical and practical attributes of curriculum systems, inadequate integration of theory and practice in teaching activities, and discrepancies between talent cultivation quality and enterprise needs. To address these issues, higher vocational colleges can enhance talent cultivation efficiency and achieve precise supply of highly skilled talents for the low-altitude economy through the following approaches: dynamically optimizing program layout guided by industrial chain demands, constructing a low-altitude economy-featured curriculum system based on modular courses, realizing in-depth integration of theory and practice through scenario-based practice, and building a demand feedback loop supported by school-enterprise collaboration.