Digital transformation restructures the interactive logic between vocational education and industrial upgrading. This study reveals the collaborative innovation mechanism of the industry-education integration system, constructing a three-spiral model of educational chain, industrial chain, and innovation chain. It proposes differentiated empowerment paths based on industry types, reshaping practical paradigms through digital twins, intelligent prediction, and blockchain technology to achieve dynamic alignment between educational supply and industrial demand. The research confirms that entrepreneurial education, by reorganizing technical elements and optimizing innovative networks, can effectively address the challenges of technological lag and talent structure imbalance in regional industrial transformation, forming a sustainable ecosystem where education drives industrial leapfrogging.