Against the backdrop of “Four-Chain” integration, regions are exploring integration pathways and methods primarily from a macro perspective. However, few studies adopt a regional micro-level viewpoint to identify breakthroughs and key points for advancing industrial development through “Four-Chain” integration, specifically in conjunction with scientific and technological functions. Starting from an analysis of the conceptual characteristics and inherent mechanisms of “Four-Chain” integration, this research combines the realities of regional economic development. It analyzes current practices and existing problems in “Four-Chain” integration, focusing on exploring the necessity and identifying specific measures and pathways for “Four-Chain” integration to drive industrial development.