As a key engine of the technological revolution, AI is accelerating deep integration with advanced manufacturing, becoming a core driver of new productivity and new industrialization. As a national leader in high-quality manufacturing and digital economy, Zhejiang has implemented the “AI+” initiative to empower its manufacturing sector. Based on a systematic review of the current integration state in Zhejiang, this paper analyzes the challenges in technological adaptation, enterprise penetration, coordination mechanisms and supporting systems. It proposes development paths from four dimensions: vertical technology breakthroughs, gradient enterprise empowerment, cluster collaboration and ecological foundation. This study aims to provide a decision-making reference for building Zhejiang into a global AI innovation hub.