Industrial digitalization is a core engine for new industrialization. By 2025, Fujian’s GDP is expected to exceed 6 trillion RMB, showing strong digital-real integration. However, challenges remain in regional balance, core technologies, supply chain synergy, and talent supply. Based on 2025 data and the “AI+” initiative, this paper analyzes these pain points and proposes five strategic countermeasures: top-level design, data element integration, supply chain synergy, industry-university-research ecosystems, and core technology breakthroughs. This study offers policy guidance for the high-quality transformation of Fujian’s manufacturing sector.