With the successive issuance and implementation of a series of policy documents represented by Opinions of the State Council on Opening Up National Major Scientific Research Infrastructure and Large-Scale Scientific Research Instruments to the Society (Guo Fa [2014] No. 70), the state and some provinces and cities have attached great importance to the opening and sharing of scientific research facilities and instruments. We have steadily promoted the efficient utilization of scientific research facility and instrument resources, and continuously enhanced their efficiency in serving social development. Against the policy background of the “Two New Initiatives” (large-scale equipment renewal and consumer goods replacement with new ones), this paper conducts a special study on the sharing service of major scientific research infrastructure and large-scale scientific instruments in combination with the actual situation of Liaoning Province. It explores a sharing service path adapted to the policy orientation and in line with regional needs, so as to provide a reference for improving the utilization efficiency of scientific and technological resources in Liaoning Province and boosting scientific and technological innovation and industrial upgrading.