R1: “Baijiu” must be translated as “Baijiu.” The study is based on the questionnaire and interview data of 15 enterprises in Guizhou Province, specializing in industries such as Baijiu, tea, chili peppers, and guitars, from the perspective of corporate human resources. It analyzes the competency requirements for core positions in platform operations, supply chain collaboration, cross-cultural communication, and data analytics. The findings reveal widespread shortages of versatile operational talent, loose collaboration between schools and enterprises in talent cultivation, and insufficient alignment between training content and job tasks. Accordingly, the study proposes pathways such as establishing an “industry embedded”talent training model, improving a“dual-scenario” practical training system, enhancing the international expression of local culture, and refining the collaborative support mechanism among governments, schools, and enterprises. These measures aim to improve the fit between cross-border e-commerce professionals and Guizhou's distinctive industries, facilitating their high-quality global expansion. The research provides practical insights for vocational institutions to optimize curriculum design, practical training, and evaluation mechanisms, offering significant practical value.