In the context of the integrated digital and intelligent transformation, the pharmaceutical and health industry faces an increasingly urgent demand for interdisciplinary digital and intelligent medical talents. Taking medical colleges and universities in Liaoning Province as the research subject, this paper analyzes the characteristics of talent supply and demand in the pharmaceutical and health industry of Liaoning Province under the digital and intelligent transformation, examines the adaptability contradictions in the industry-education integration cultivation mechanisms of medical colleges in the province, and constructs a cultivation mechanism characterized by “digital and intelligent leadership, industry-education symbiosis, and multi-stakeholder collaboration”. It further provides practical pathways for medical colleges in Liaoning Province to empower the high-quality development of the regional pharmaceutical and health industry.