This paper construct an indicator system by comprehensively utilizing AHP and entropy weight method to evaluate the security level of Liaoning’s high-tech industry chain including value chain, enterprise chain, supply and demand chain, and spatial chain. The results show that the security level has fluctuated and increased from 2010 to 2023, and the performance differs across sub-sectors. To promote safer development, Liaoning should leverage existing advantages, focus on shortcomings, strengthen independent innovation capabilities.