To accelerate regional economic development, this study examines feasible pathways for digital transformation in Guizhou Province’s economy and industries. By analyzing GDP data from nine cities and assessing the current state of tourism industrial parks, it identifies key drivers of digital transformation. The research reveals that GDP growth rates of 6.4% in Guiyang and 5.6% in Zunyi provide solid economic foundations, while case studies— including a 300% surge in users for the “One Code Tour Guizhou” app and Wanfenglin Tourism Group securing ¥10 million in data asset financing—demonstrate practical viability. Accordingly, a framework of “platform development – data management – policy coordination” is proposed: establishing industry chain integration platforms through leading enterprises, creating industrial funds with tax incentives, developing unified data standards for cultural tourism products, and formulating regional digital plans to enhance government-enterprise collaboration. These findings offer valuable insights for advancing digital transformation across southwestern China’s economic sectors.