By constructing a four-dimensional effect evaluation system, an efficiency analysis is conducted on the input and output levels of Nanyang’s science and technology finance. Research has found that the empowerment mechanism of science and technology finance in Nanyang has initially taken shape, but there are problems such as low innovation output efficiency, small scale of leading enterprises, and regional development differentiation. Facing the “15th Five Year Plan” period, Nanyang should strengthen multi-level supply of science and technology finance, cultivate innovative entities, promote regional coordinated development, and enhance the empowering effect of science and technology finance on strategic emerging industries.