To promote in-depth collaboration between universities and enterprises in Henan Province, foster the integration of industry, academia, research, and application, and enhance the rate of scientific and technological achievement transformation, this study takes universities in Henan Province as the research subject to explore the influencing factors, models, and innovative strategies for the transfer and transformation of university scientific and technological achievements. The findings reveal that the maturity and value of scientific and technological achievements, are the primary factors affecting the transfer and transformation of university scientific and technological achievements. Currently, the main models for the transformation of university scientific and technological achievements in Henan Province include market transformation, technology transfer, and the “industry-academia-research” model. To address this, innovative approaches are proposed, including improving management mechanisms, upgrading traditional models, establishing service platforms, and policy support. The study demonstrates that by advancing the innovation of university scientific and technological achievement transfer and transformation models through multiple dimensions, multidisciplinary cross-disciplinary development can be promoted, better serving regional economic growth.