合成生物技术作为第三次生命科学革命的核心方向，其产业化进程高度依赖科技创新与产业创新的深度融合。在国家战略布局与技术迭代双重驱动下，我国合成生物产业规模持续扩张，但科产融合中的“全链条断裂”“多主体协同不足”等问题制约了产业化效率。基于科产融合理论、三重螺旋模型与产业生态系统理论，构建“技术—主体—场景—制度”四维分析框架，选取深圳、天津、常州、合肥四大典型区域开展多案例实证研究。研究发现：四大区域形成了差异化科产融合模式，其核心差异体现在融合载体、动力来源与协同机制上；技术工程化能力薄弱、主体协同网络松散、高价值场景缺失、制度供给适配性不足是共性瓶颈。据此提出“技术攻坚—主体协同—场景赋能—制度创新”四位一体的产业化生态构建路径，为各地推进合成生物科产融合提供理论支撑与实践参考。

As the core direction of the third revolution in life sciences, the industrialization of synthetic biotechnology highly relies on the integration of scientific and technological innovation and industrial innovation. Driven by both national strategic layout and technological iteration, the scale of China’s synthetic biology industry has continued to expand. However, problems such as “full-chain fragmentation” and “insufficient multi-agent collaboration” in integration of science and production have constrained industrialization efficiency. Based on the theory of science industry integration, the Triple Helix Model, and the theory of industrial ecosystems, this study constructs a four dimensional analytical framework of “technology-agent-scenario-institution” .Multi-case empirical research is conducted in four typical regions: Shenzhen, Tianjin, Changzhou, and Hefei. The research finds that the four regions have formed differentiated science-industry integration models, with core differences reflected in integration carriers, power sources, and collaborative mechanisms. Common bottlenecks include weak technological engineering capabilities, loose collaborative networks among agents, lack of high-value scenarios, and insufficient adaptability of institutional supply. Accordingly, this study proposes a path for industrial ecosystem construction: “technological breakthroughs-multi-agent collaboration-scenario empowerment-institutional innovation,” providing theoretical support and practical reference for promoting the integration of synthetic biology science and industry in various regions.